Importance Nowadays, petrochemical enterprises show increasing interest in various methods to assess innovative capacity and to manage innovation-driven development. The petrochemical industry is generally represented by large holdings. Therefore, it is critical for them to have a methodology to assess the readiness of subsidiaries incorporated in a holding to introduce innovation. Objectives The study aims to create a system of indicators to assess the readiness of petrochemical enterprises to implement innovation projects, considering the specifics of the industry and the interest of the parent company of the holding in high return on investment. Methods The study draws on the systems approach, general scientific methods of analysis and synthesis, and expert, statistical, graphical methods and techniques. Results The analysis of the petrochemical industry helped define its status and development prospects. We created a system of indicators consisting of five groups to determine the appeal of petrochemical enterprises. The offered system assesses the internal environment of the organization and demonstrates how the latter is prepared to introduce innovation from the perspective of its production, finance, personnel, etc. Conclusions If used in practice, the offered system will enable a detailed due diligence of petrochemical enterprises and assist the holding's parent in making management decisions when preparing plans for investing in subsidiaries.