Subject. This article discusses the importance of border regions in the economic development of the country in the context of international sanctions. Objectives. The article aims to identify trends and areas of development of border regions in the context of global challenges. Methods. For the study, we used the general scientific research methods. Results. Based on the analysis of the economic indicators of the regions of the Russian-Kazakh border-zone, the article offers the author-developed recommendations for the development of the structure of export-import flows in the regions under study. Conclusions. The border regions of the Russian Federation are experiencing strong sanctions pressure. This has a negative impact on the weakest regions in economic terms, while more developed and economically stable regions adapt more effectively to negative trends.
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