Subject This article discusses various aspects of the innovative development of cross-border natural and economic systems of the Tyva Republic. Objectives The article aims to analyze the specifics of the development of these systems. Methods For the study, I used the methods of comparison, dynamics, extrapolation, and tabular and graphic representation of the results obtained. Results The article identifies the lagging regions and regions with the highest rates of innovation-driven development in the Siberian Federal District. The point forecast and linear regressional dependences of summarizing innovation indicators show a decrease in the innovation activities of the organizations of the Tyva Republic. Conclusions Implementation of innovation-driven development of cross-border natural and economic systems of the Tyva Republic is possible and feasible, as well, only on the basis of public-private partnership.
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